Title : Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides.

Pub. Date : 2014 May

PMID : 24566469






1 Functional Relationships(s)
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1 421, 79-86, 2009) that nitroxides, including 4-amino-TEMPO (4-amino-2,2,6,6-tetramethylpiperidin-1-yloxyl radical), are potent inhibitors of HOCl formation by isolated MPO and activated neutrophils, with IC50 values of ~1 and ~6 microM respectively. Hydroxylamine myeloperoxidase Homo sapiens