Title : EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control.

Pub. Date : 2014

PMID : 24558360






5 Functional Relationships(s)
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1 EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
2 The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
3 The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
4 In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
5 In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus