Title : In vivo disposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters.

Pub. Date : 2014 Oct 1

PMID : 24554572






2 Functional Relationships(s)
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1 Interestingly, transgenic liver-specific expression of human OATP1A2, OATP1B1 or OATP1B3 could partially rescue the increased doxorubicin plasma levels of Oatp1a/1b(-/-) mice. Doxorubicin solute carrier organic anion transporter family member 1B3 Homo sapiens
2 Hepatic uptake and bile-derived intestinal excretion of doxorubicin were completely reverted to wild-type levels by OATP1A2, and partially by OATP1B1 and OATP1B3. Doxorubicin solute carrier organic anion transporter family member 1B3 Homo sapiens