Title : Serum half-life and biological activity of mutants of human insulin-like growth factor I which do not bind to serum binding proteins.

Pub. Date : 1988 Jul

PMID : 2454805






2 Functional Relationships(s)
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1 Despite decreased serum half-lives, the B-chain mutant and [Gln3,Ala4,Tyr15,Leu16]IGF-I are, respectively, 4 times and twice as active as IGF-I in stimulating the incorporation of [14C]glucose into glycogen in rat diaphragm in vivo. Carbon-14 insulin-like growth factor 1 Rattus norvegicus
2 Despite decreased serum half-lives, the B-chain mutant and [Gln3,Ala4,Tyr15,Leu16]IGF-I are, respectively, 4 times and twice as active as IGF-I in stimulating the incorporation of [14C]glucose into glycogen in rat diaphragm in vivo. Carbon-14 insulin-like growth factor 1 Rattus norvegicus