Pub. Date : 2014 Apr
PMID : 24534773
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Resveratrol supplementation effectively counteracts TNF-alpha induced muscle protein loss and reverses declining expression of Akt, mTOR, p70S6K, 4E-BP1and FoxO1, but exerts no influence of FoxO3a expression. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Our study demonstrates that resveratrol can reverse the muscle cell atrophy caused by TNF-alpha through regulation of the Akt/mTOR/FoxO1 signaling pathways, followed by inhibition of the atrophy-related ubiquitin ligase. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |