Pub. Date : 2014 Mar 28
PMID : 24526685
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-beta synthesis in macrophages. | Tyrosine | toll like receptor 3 | Homo sapiens |
2 | Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subsequently triggers signaling pathways to promote interferon-beta (IFN-beta) production. | Tyrosine | toll like receptor 3 | Homo sapiens |
3 | Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subsequently triggers signaling pathways to promote interferon-beta (IFN-beta) production. | Tyrosine | toll like receptor 3 | Homo sapiens |
4 | In this study, we found that dsRNA stimulation induces biphasic TLR3 Tyr-759 phosphorylation in macrophages. | Tyrosine | toll like receptor 3 | Homo sapiens |
5 | Interestingly, Src phosphorylated TLR3 Tyr-759 in vitro and in vivo. | Tyrosine | toll like receptor 3 | Homo sapiens |
6 | However, knockdown of Src abolished the late phase of TLR3 Tyr-759 phosphorylation and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and IFN-beta production. | Tyrosine | toll like receptor 3 | Homo sapiens |
7 | Notably, via down-regulation of Src, dsRNA-elicited TLR3 Tyr-759 phosphorylation, the nuclear accumulation of IRF3/IRF7, and IFN-beta generation were inhibited in inducible nitric-oxide synthase (iNOS)-null macrophages. | Tyrosine | toll like receptor 3 | Homo sapiens |