Title : The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-β synthesis in macrophages.

Pub. Date : 2014 Mar 28

PMID : 24526685






7 Functional Relationships(s)
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1 The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-beta synthesis in macrophages. Tyrosine toll like receptor 3 Homo sapiens
2 Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subsequently triggers signaling pathways to promote interferon-beta (IFN-beta) production. Tyrosine toll like receptor 3 Homo sapiens
3 Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subsequently triggers signaling pathways to promote interferon-beta (IFN-beta) production. Tyrosine toll like receptor 3 Homo sapiens
4 In this study, we found that dsRNA stimulation induces biphasic TLR3 Tyr-759 phosphorylation in macrophages. Tyrosine toll like receptor 3 Homo sapiens
5 Interestingly, Src phosphorylated TLR3 Tyr-759 in vitro and in vivo. Tyrosine toll like receptor 3 Homo sapiens
6 However, knockdown of Src abolished the late phase of TLR3 Tyr-759 phosphorylation and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and IFN-beta production. Tyrosine toll like receptor 3 Homo sapiens
7 Notably, via down-regulation of Src, dsRNA-elicited TLR3 Tyr-759 phosphorylation, the nuclear accumulation of IRF3/IRF7, and IFN-beta generation were inhibited in inducible nitric-oxide synthase (iNOS)-null macrophages. Tyrosine toll like receptor 3 Homo sapiens