Title : Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid β-fibrils in a redox cycle.

Pub. Date : 2014 Apr 4

PMID : 24523414






1 Functional Relationships(s)
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1 Our photometric studies confirmed the production of ~60 muM hydrogen peroxide (H2O2) from a solution of 20 muM Cu(2+) ions in complex with Abeta(1-40) in fibrils ([Cu(2+)]/[Abeta] = 0.4) within 2 h of incubation after addition of biological reducing agent ascorbate at the physiological concentration (~1 mM). Ascorbic Acid amyloid beta precursor protein Homo sapiens