Title : Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation.

Pub. Date : 2014 May 1

PMID : 24512768






3 Functional Relationships(s)
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1 Rutin improves spatial memory in Alzheimer"s disease transgenic mice by reducing Abeta oligomer level and attenuating oxidative stress and neuroinflammation. Rutin amyloid beta (A4) precursor protein Mus musculus
2 Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric Abeta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1beta and IL-6 levels in the brain. Rutin amyloid beta (A4) precursor protein Mus musculus
3 These results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing Abeta oligomer activities. Rutin amyloid beta (A4) precursor protein Mus musculus