Pub. Date : 2014
PMID : 24490130
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NFkappaB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC). | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We found that pharmacological induction of histone acetylation using HDAC inhibitors prevented NFkappaB-induced cisplatin resistance. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Furthermore, silencing NFkappaB in HNSCC induced acetylation of tumor histones, resulting in reduced chemoresistance and increased cytotoxicity following cisplatin treatment. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |