Title : Neuroprotective effects of 3,6'-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1/2 pathway.

Pub. Date : 2014 Aug

PMID : 24488601






1 Functional Relationships(s)
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1 Pharmacological inhibition of mitogen-activated protein kinase 1 (ERK1/2), CaMKII, and Trk (with U0126, KN93, or K252a, respectively) partially attenuated the stimulatory effect of DISS on phospho-CREB and BDNF expression; however, it was not inhibited by pharmacological inhibition of PKA or PI3K (with H89 and LY294002, respectively). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens