Title : Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo.

Pub. Date : 2014 Jan 30

PMID : 24481444






2 Functional Relationships(s)
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1 However, Sorafenib-mediated activation of caspase-3 and induction of apoptosis were exclusively found in hepatoma cells, but not in matching primary hepatocytes. Sorafenib caspase 3 Mus musculus
2 Sorafenib treatment activated caspase-3 and thus apoptosis selectively in small tumor foci that originated from implanted Hepa1-6 cells but not in surrounding healthy hepatocytes. Sorafenib caspase 3 Mus musculus