Pub. Date : 2014 Jan 27
PMID : 24468065
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 2 | BACKGROUND: miRNAs are involved in osteosarcoma (OS) chemoresistance, and TWIST reportedly enhances cisplatin-induced OS cell apoptosis by inhibiting multiple signaling pathways. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 3 | In Saos-2 cells treated with cisplatin, inhibition of miR-33a by antagomir-33a markedly increased cell apoptosis, which was enhanced by overexpression of TWIST. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 4 | In MG-63 cells, overexpression of miR-33a significantly decreased cisplatin-induced cell apoptosis, which was enhanced by knockdown of TWIST. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 5 | Antagomir-33a significantly increased cisplatin-induced cell apoptosis, which was reversed by knockdown of TWIST. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 6 | Our in vitro data indicate that miR-33a promotes OS cell resistance to cisplatin by down-regulating TWIST; on the other hand, inhibition of miR-33a by antagomir-33a enhances cisplatin-induced apoptosis in OS cells by up-regulating TWIST expression. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |
| 7 | Our in vitro data indicate that miR-33a promotes OS cell resistance to cisplatin by down-regulating TWIST; on the other hand, inhibition of miR-33a by antagomir-33a enhances cisplatin-induced apoptosis in OS cells by up-regulating TWIST expression. | Cisplatin | twist family bHLH transcription factor 1 | Homo sapiens |