Pub. Date : 2014 Jan
PMID : 24464600
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | It is previously shown that carriers of the defective allele CYP2C9*3 that leads to impaired sulfonylurea metabolism are at increased sulfonylurea-induced hypoglycemia risk due to diminished drug metabolism, whereas no effect of CYP2C9*2 allele was found. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | In a model adjusted for age, BMI, duration of T2DM and renal function, and POR*1/*1 entered as a selection variable, CYP2C9*2 allele increased the hypoglycemia risk in response to sulfonylurea (odds ratio: 3.218, p=0.031). | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | In conclusion, our results suggest that POR*28 allele is masking the association of CYP2C9*2 allele with sulfonyl-urea-induced hypoglycemia. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | Therefore, POR*28 allele is an important source of CYP2C9 activity variability and combined with CYP2C9 gene poly-morphisms may explain individual variability in the effect of sulfonylureas. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |