Pub. Date : 2014 Apr
PMID : 24463049
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 2 | Compared with old controls, long-term administration of atorvastatin to old rats inhibited the senescent phenotype (p<0.05), improved endothelium-dependent relaxation (p<0.05 or 0.01), decreased MDA (p<0.01), increased SOD, NO, eNOS, and SIRT1 expression (p<0.01), and inhibited iNOS expression (not detectable) in aged rat aortas. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 3 | The results indicate that the long-term administration of atorvastatin improves age-related endothelial dysfunction in aged rats via inhibition of the senescent phenotype, amelioration of oxidative stress, and normalization of eNOS/iNOS imbalance. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |