Title : Lead optimization on conventional non-steroidal anti-inflammatory drugs: an approach to reduce gastrointestinal toxicity.

Pub. Date : 2014 Jul

PMID : 24460671






1 Functional Relationships(s)
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1 Classic non-steroidal anti-inflammatory drugs such as meclofenamic acid and indomethacin inhibit both isoforms of cyclooxygenase non-selectively or with low selectivity, exerting their anti-inflammatory activity via inhibiting cyclooxygenase-2, and their deleterious side-effects by inhibiting cyclooxygenase-1. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens