Pub. Date : 2013
PMID : 24460329
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-21 upregulation induced by promoter zone histone acetylation is associated with chemoresistance to gemcitabine and enhanced malignancy of pancreatic cancer cells. | gemcitabine | microRNA 21 | Homo sapiens |
| 2 | BACKGROUND AND AIMS: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs). | gemcitabine | microRNA 21 | Homo sapiens |
| 3 | BACKGROUND AND AIMS: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs). | gemcitabine | microRNA 21 | Homo sapiens |
| 4 | Histone acetylation in the miR-21 promoter was also studied in gemcitabine-sensitive and gemcitabine-resistant PDAC cells. | gemcitabine | microRNA 21 | Homo sapiens |
| 5 | Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA. | gemcitabine | microRNA 21 | Homo sapiens |
| 6 | Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA. | gemcitabine | microRNA 21 | Homo sapiens |
| 7 | Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA. | gemcitabine | microRNA 21 | Homo sapiens |
| 8 | RESULTS: Serum miR-21 levels were increased in gemcitabine- resistant PDAC patients compared with gemcitabine-sensitive subjects. | gemcitabine | microRNA 21 | Homo sapiens |
| 9 | RESULTS: Serum miR-21 levels were increased in gemcitabine- resistant PDAC patients compared with gemcitabine-sensitive subjects. | gemcitabine | microRNA 21 | Homo sapiens |
| 10 | The miR-21 levels were increased in 6 PDAC cells treated with gemcitabine significantly, associated with 50% inhibitory concentrations (IC50s). | gemcitabine | microRNA 21 | Homo sapiens |
| 11 | Histone acetylation levels at miR-21 promoter were increased in PDAC cells after treatment with gemcitabine. | gemcitabine | microRNA 21 | Homo sapiens |
| 12 | Enhanced invasion and metastasis, increased miR-21 expression, decreased PTEN, elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells. | gemcitabine | microRNA 21 | Homo sapiens |
| 13 | In contrast, anti-miR-21 transfection could reverse invasion and metastasis, and PTEN and pAKT expressions induced by gemcitabine. | gemcitabine | microRNA 21 | Homo sapiens |
| 14 | CONCLUSIONS: MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells. | gemcitabine | microRNA 21 | Homo sapiens |