PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24460329-0	2013	MiR-21 upregulation induced by promoter zone histone acetylation is associated with chemoresistance to gemcitabine and enhanced malignancy of pancreatic cancer cells.	gemcitabine	103-114	microRNA 21	Homo sapiens	0-6	
24460329-1	2013	BACKGROUND AND AIMS: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs).	gemcitabine	124-135	microRNA 21	Homo sapiens	21-32	
24460329-1	2013	BACKGROUND AND AIMS: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs).	gemcitabine	124-135	microRNA 21	Homo sapiens	34-40	
24460329-4	2013	Histone acetylation in the miR-21 promoter was also studied in gemcitabine-sensitive and gemcitabine-resistant PDAC cells.	gemcitabine	63-74	microRNA 21	Homo sapiens	27-33	
24460329-5	2013	Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA.	gemcitabine	0-11	microRNA 21	Homo sapiens	70-76	
24460329-5	2013	Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA.	gemcitabine	0-11	microRNA 21	Homo sapiens	93-99	
24460329-5	2013	Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA.	gemcitabine	0-11	microRNA 21	Homo sapiens	93-99	
24460329-7	2013	RESULTS: Serum miR-21 levels were increased in gemcitabine- resistant PDAC patients compared with gemcitabine-sensitive subjects.	gemcitabine	47-58	microRNA 21	Homo sapiens	15-21	
24460329-7	2013	RESULTS: Serum miR-21 levels were increased in gemcitabine- resistant PDAC patients compared with gemcitabine-sensitive subjects.	gemcitabine	98-109	microRNA 21	Homo sapiens	15-21	
24460329-8	2013	The miR-21 levels were increased in 6 PDAC cells treated with gemcitabine significantly, associated with 50% inhibitory concentrations (IC50s).	gemcitabine	62-73	microRNA 21	Homo sapiens	4-10	
24460329-9	2013	Histone acetylation levels at miR-21 promoter were increased in PDAC cells after treatment with gemcitabine.	gemcitabine	96-107	microRNA 21	Homo sapiens	30-36	
24460329-10	2013	Enhanced invasion and metastasis, increased miR-21 expression, decreased PTEN, elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells.	gemcitabine	120-131	microRNA 21	Homo sapiens	44-50	
24460329-12	2013	In contrast, anti-miR-21 transfection could reverse invasion and metastasis, and PTEN and pAKT expressions induced by gemcitabine.	gemcitabine	118-129	microRNA 21	Homo sapiens	18-24	
24460329-13	2013	CONCLUSIONS: MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells.	gemcitabine	123-134	microRNA 21	Homo sapiens	13-19