Title : Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring.

Pub. Date : 2013

PMID : 24454363






3 Functional Relationships(s)
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Protein Name
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1 Prenatal exposure to PAH was associated with reduced beta 2AR gene expression among nonsensitized mice offspring, but not increases in DNA methylation or AHR. Polycyclic Aromatic Hydrocarbons adrenergic receptor, beta 2 Mus musculus
2 In the first study that delivers PAH aerosols to mice in a relatively physiological manner, small effects on AHR and beta 2AR gene expression, but not beta 2AR agonist drug activity, were observed. Polycyclic Aromatic Hydrocarbons adrenergic receptor, beta 2 Mus musculus
3 If confirmed, the results may suggest that exposure to PAH, common ambient urban pollutants, affects beta 2AR function, although the impact on the efficacy of beta 2AR agonist drugs used in treating asthma remains uncertain. Polycyclic Aromatic Hydrocarbons adrenergic receptor, beta 2 Mus musculus