Title : First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers.

Pub. Date : 2014 Mar

PMID : 24452393






1 Functional Relationships(s)
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1 A significant increase in uracil Cmax was observed at administered doses of 150 mg or higher of TAS-114, suggesting that significant inhibition of DPD occurred at these doses. Uracil dihydropyrimidine dehydrogenase Homo sapiens