Title : Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy.

Pub. Date : 2014 Jan 14

PMID : 24446315






2 Functional Relationships(s)
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1 Individuals with XPD 711 Asp and XPD 312 Asn alleles responded poorly to chemotherapy when compared with the wide-type genotype. Aspartic Acid ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens
2 On the other hand, the XPD 711 Asp allele was associated with poorer progression free survival and overall survival compared to the C/C genotype, with HRs of 1.89 and 1.90. Aspartic Acid ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens