CPRiL

Protein Name	ERCC excision repair 2, TFIIH core complex helicase subunit
Organism	Homo sapiens
Gene ID	2068
Gene Symbol	ERCC2
UniProt	P18074 (ERCC2_HUMAN)
Relationships	Total Number of functionally related compound(s) : 167 Total Number of Articles : 366
Description	ERCC excision repair 2, TFIIH core complex helicase subunit
Gene Summary	The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
synonyms	general transcription and DNA repair factor IIH helicase subunit XPD BTF2 p80 CXPD DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells TFIIH 80 kDa subunit TFIIH basal transcription factor complex 80 kDa subunit TFIIH basal transcription factor complex helicase XPB subunit TFIIH basal transcription factor complex helicase XPD subunit TFIIH basal transcription factor complex helicase subunit TFIIH p80 TFIIH subunit XPD basic transcription factor 2 80 kDa subunit excision repair cross-complementation group 2 excision repair cross-complementing rodent repair deficiency, complementation group 2 xeroderma pigmentosum complementary group D xeroderma pigmentosum group D-complementing protein COFS2 EM9 TFIIH TTD TTD1 XPD Click to show/hide the synonyms
Properties