Pub. Date : 2014 Apr 1
PMID : 24445604
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In primary cultured CAMs, CD38 gene deletion markedly enhanced 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer)-induced accumulation of autophagosomes and increased expression of an autophagic marker, LC3B. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 2 | In primary cultured CAMs, CD38 gene deletion markedly enhanced 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer)-induced accumulation of autophagosomes and increased expression of an autophagic marker, LC3B. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 3 | Further, 7-Ket-induced formation of autophagolysosomes was markedly attenuated in CD38(-/-) CAMs compared with CD38(+/+) CAMs. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 4 | Further, 7-Ket-induced formation of autophagolysosomes was markedly attenuated in CD38(-/-) CAMs compared with CD38(+/+) CAMs. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 5 | Mechanistically, CD38 gene deletion markedly inhibited 7-Ket-induced dynein activation and autophagosome trafficking, which were associated with attenuated lysosomal Ca(2+) release. | 7-ketocholesterol | CD38 antigen | Mus musculus |