Title : IRF5 is a target of BCR-ABL kinase activity and reduces CML cell proliferation.

Pub. Date : 2014 May

PMID : 24445143






2 Functional Relationships(s)
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1 We report that IRF5 is expressed in CML cells, where it interacts with the BCR-ABL kinase that modulates its expression and induces its tyrosine phosphorylation. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Interestingly, a mutant devoid of a BCR-ABL consensus site (IRF5(Y104F)) still presented significant tyrosine phosphorylation. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens