Title : Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL is a biologically functional cut-point.

Pub. Date : 2014 Jul

PMID : 24444338






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We further studied how NAb titers affected in vivo transcription of IFN-induced genes myxovirus resistant 1 (MX1) and C-X-C motif chemokine 10 (CXCL10), in addition to serum CXCL10 protein levels. nab MX dynamin like GTPase 1 Homo sapiens
2 MX1 and CXCL10 gene expression was strongly induced by IFNbeta and NAb positivity significantly reduced this expression. nab MX dynamin like GTPase 1 Homo sapiens
3 A NAb titer of 150 TRU/mL was observed to be a biological cut-point applicable to both assays, since MX1 and CXCL10 expression was greatly reduced or blocked in patients above this titer level. nab MX dynamin like GTPase 1 Homo sapiens