Pub. Date : 2014 Mar
PMID : 24436324
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats. | Pyruvaldehyde | renin | Rattus norvegicus |
| 2 | RESULTS: Methylglyoxal-treated rats developed a significant increase in blood pressure and plasma levels of aldosterone, renin, angiotensin, and catecholamines. | Pyruvaldehyde | renin | Rattus norvegicus |
| 3 | Methylglyoxal level and protein and mRNA for angiotensin, AT1 receptor, adrenergic alpha1D receptor, and renin were significantly increased in the aorta and/or kidney of methylglyoxal-treated rats, a novel finding. | Pyruvaldehyde | renin | Rattus norvegicus |
| 4 | CONCLUSIONS: Methylglyoxal activates NF-kappaB through RAGE and thereby increases renin-angiotensin levels, a novel finding, and a probable mechanism of increase in blood pressure. | Pyruvaldehyde | renin | Rattus norvegicus |