Pub. Date : 2014
PMID : 24434352
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-kappaB signaling pathway. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | METHODS: The effect of celastrol on PI3K/Akt and the NF-kappaB signaling pathway was evaluated with Western blot and luciferase reporter assay. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | RESULTS: It was identified that celastrol was capable of inducing apoptosis of gastric cancer cells, which was mediated via inhibiting the activation of PI3K/Akt and NF-kappaB. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | A strong activator of Akt, IGF-1 restored NF-kappaB activity in cells treated with celastrol. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Notably, upregulation of miR-21 expression can increase PI3K/Akt and NF-kappaB activity and decrease apoptosis of gastric cancer cells treated with celastrol, which could be reversed by PI3K inhibitor. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our data revealed that the effect of celastrol on apoptosis was due to miR-21 inhibiting the PI3K/Akt-dependent NF-kappaB pathway. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |