Title : Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells.

Pub. Date : 2014 Apr

PMID : 24431215






4 Functional Relationships(s)
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1 Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
2 Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
3 BaP- and BPDE-activated NF-kappaB-p65 protein phosphorylation could also be attenuated by both AhR and ER inhibitors. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
4 These results suggest that both BaP and BPDE are capable of inhibiting myogenesis via an AhR- or/and ER-regulated NF-kappaB/Akt signaling pathway. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens