Title : Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases.

Pub. Date : 2014 Jun

PMID : 24429914






5 Functional Relationships(s)
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1 Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases. Dexmedetomidine interleukin 6 Homo sapiens
2 This study was designed to evaluate the effects of DEX on tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) gene expressions in LPS-challenged astrocytes. Dexmedetomidine interleukin 6 Homo sapiens
3 This study was designed to evaluate the effects of DEX on tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) gene expressions in LPS-challenged astrocytes. Dexmedetomidine interleukin 6 Homo sapiens
4 With real-time PCR assay, we found that LPS significantly increased expressions of TNF-alpha and IL-6 in mRNA level; however, these effects could be attenuated by DEX. Dexmedetomidine interleukin 6 Homo sapiens
5 Furthermore, JNK pathway might be involved in LPS-induced astrocyte activation because JNK phosphorylation was significantly increased, and the inhibition of this pathway mediated by DEX as well as SP600125 (JNK inhibitor) decreased TNF-alpha and IL-6 expressions. Dexmedetomidine interleukin 6 Homo sapiens