Title : Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.

Pub. Date : 2014 Mar

PMID : 24424044






1 Functional Relationships(s)
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1 In this study, we demonstrated that the liver-enriched transcription factor CREBH (cAMP-responsive element binding protein, hepatocyte specific) and peroxisome proliferator-activated receptor alpha (PPARalpha) function as binary transcriptional activators to regulate lipid metabolism by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis. Cyclic AMP peroxisome proliferator activated receptor alpha Mus musculus