Pub. Date : 2014 Mar
PMID : 24418212
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although the kB site-NF-kappaB protein interaction was significantly perturbed by DNA adducts of cisplatin, transplatin adducts were markedly less effective both in cell-free media and in cellulo using a decoy strategy derivatized-approach. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Moreover, NF-kappaB inhibitor JSH-23 [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine] augmented cisplatin cytotoxicity in ovarian cancer cells and the data showed strong synergy with JSH-23 for cisplatin. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Moreover, NF-kappaB inhibitor JSH-23 [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine] augmented cisplatin cytotoxicity in ovarian cancer cells and the data showed strong synergy with JSH-23 for cisplatin. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Because thousands of kappaB sites are present in the DNA, the mechanisms underlying the antitumor efficiency of cisplatin in some tumor cells may involve downstream processes after inhibition of the binding of NF-kappaB to kappaB site(s) by DNA adducts of cisplatin, including enhanced programmed cell death in response to drug treatment. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Because thousands of kappaB sites are present in the DNA, the mechanisms underlying the antitumor efficiency of cisplatin in some tumor cells may involve downstream processes after inhibition of the binding of NF-kappaB to kappaB site(s) by DNA adducts of cisplatin, including enhanced programmed cell death in response to drug treatment. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |