Pub. Date : 2014 Apr
PMID : 24413389
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | ursolic acid | heme oxygenase 1 | Homo sapiens |
| 2 | HO-1 in Kasumi-1 cells was upregulated by being treated with low-dose rather than high-dose UA. | ursolic acid | heme oxygenase 1 | Homo sapiens |
| 3 | Inhibition of HO-1 by zinc protoporphyrin (ZnPP) IX sensitized Kasumi-1 cells to UA, and the apoptotic rate was close to that induced by Ara-C (P<0.01). | ursolic acid | heme oxygenase 1 | Homo sapiens |
| 4 | After silencing HO-1 by siRNA transfection with lentivirus, the cells" proliferation induced by UA was increased as it was by Ara-C. | ursolic acid | heme oxygenase 1 | Homo sapiens |
| 5 | AML-M2 can feasibly be treated by target-inhibiting HO-1 that enhances the antileukemia effects of UA in vitro and in vivo. | ursolic acid | heme oxygenase 1 | Homo sapiens |