Title : Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?

Pub. Date : 2014 Feb 17

PMID : 24410629






1 Functional Relationships(s)
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1 The major event of the mechanism of their mutagenicity is N-hydroxylation by P450 enzymes, primarily P450 1A2 (CYP1A2), which leads to the formation of nitrenium ions that covalently modify nucleobases of DNA. nitrenium cytochrome P450 family 1 subfamily A member 2 Homo sapiens