Title : Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.

Pub. Date : 2014 Feb 19

PMID : 24409989






1 Functional Relationships(s)
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1 Polymer based carriers that aid in endosomal escape have proven to be efficacious siRNA delivery agents in vitro and in vivo; however, most suffer from cytotoxicity due in part to a lack of selectivity for endosomal versus cell membrane lysis. Polymers activation induced cytidine deaminase Homo sapiens