Title : Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice.

Pub. Date : 2014 Jan 9

PMID : 24407238






1 Functional Relationships(s)
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1 5"-AMP failed to attenuate LPS-induced nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation, but reduced LPS-induced recruitment of NF-kappaB p65 to inflammatory gene promoters and decreased LPS-induced enrichment of H3K4 dimethylation at the tumor necrosis factor-alpha (TNF-alpha) promoter, which was involved in 5"-AMP-induced elevation of cellular adenosine and a decline of methylation potential. Adenosine Monophosphate nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus