Pub. Date : 2013 Dec
PMID : 24403860
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of AMPK by metformin triggered a growth inhibitory signal but also increased BCA2 protein levels, which correlated with AKT activation and could be curbed by an AMPK inhibitor, suggesting a potential feedback mechanism from pAMPKalpha1 to pAkt to BCA2. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Finally, BCA2 siRNA, or inhibition of its upstream stabilizing kinase AKT, increased the growth inhibitory effect of metformin in multiple breast cancer cell lines, supporting the conclusion that BCA2 weakens metformin"s efficacy. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Finally, BCA2 siRNA, or inhibition of its upstream stabilizing kinase AKT, increased the growth inhibitory effect of metformin in multiple breast cancer cell lines, supporting the conclusion that BCA2 weakens metformin"s efficacy. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |