Pub. Date : 2013
PMID : 24399733
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells. | ursolic acid | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells. | ursolic acid | poly(ADP-ribose) polymerase 1 | Homo sapiens |