Pub. Date : 2014 Nov
PMID : 24397597
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that quercetin inhibited the proliferation of MM cells in a dose- and time-dependent manner, accompanied by reduced IQGAP1 expression at mRNA and protein levels, and reduced extracellular signal-regulated kinase 1/2 (ERK1/2) activation. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
2 | In summary, our results suggest that quercetin suppresses the proliferation of MM cells by down-regulating IQGAP1 expression and ERK activation, and has potential as a novel agent to target oncogenic kinase cascades for MM therapy. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |