Title : Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-β2 and NADPH oxidase.

Pub. Date : 2013

PMID : 24396568






1 Functional Relationships(s)
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1 Primary cultured human umbilical vein endothelial cells were either treated or untreated with TNF- alpha (40 ng/mL) alone or in the presence of the specific PKC- beta2 inhibitor CGP53353 (1 muM)), nitroglycerine (10 muM), propofol (100 muM), propofol plus nitroglycerin, or CGP53353 plus nitroglycerine, respectively, for 24 hours. 4,5-dianilinophthalimide latexin Homo sapiens