Title : Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.

Pub. Date : 2014 Jan 6

PMID : 24387758






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1 CONCLUSION: We showed that parthenolide not only triggered extrinsic apoptosis by up-regulating TNFRSF10B and down-regulating CFLAR, but also induced intrinsic apoptosis through increasing the expression of PMAIP1 and decreasing the level of MCL1 in NSCLC cells. parthenolide CASP8 and FADD like apoptosis regulator Homo sapiens