Title : PAR-1 activation rescues astrocytes through the PI3K/Akt signaling pathway from chemically induced apoptosis that is exacerbated by gene silencing of β-arrestin 1.

Pub. Date : 2014 Feb

PMID : 24378649






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1 Furthermore, application of thrombin rescues beta-arrestin 1-lacking astrocytes from apoptosis by enhanced Akt (Ser 473) phosphorylation. Serine coagulation factor II, thrombin Homo sapiens
2 Our most striking novel finding is that beta-arrestin 1 inhibits long-term thrombin-stimulated phosphorylation of Akt (Ser 473). Serine coagulation factor II, thrombin Homo sapiens
3 In addition, we also found that thrombin-induced phosphorylation of Akt (Ser 473) is increased by transactivation of the EGF and PDGF receptors in beta-arrestin 1-silenced astrocytes. Serine coagulation factor II, thrombin Homo sapiens