Title : Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.

Pub. Date : 2014 May

PMID : 24375927






2 Functional Relationships(s)
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1 Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. Pyrrolizidine Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens
2 The passage of the noncyclic PA Hn and Em is reduced by an ABCB1-driven efflux into the gastrointestinal lumen resulting in a decreased oral bioavailability. Pyrrolizidine Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens