Title : Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1).

Pub. Date : 1987 May 18

PMID : 2437428






4 Functional Relationships(s)
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1 Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine plasminogen Mus musculus
2 Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine plasminogen Mus musculus
3 In the mice pretreated with PLG, although the striatal dopamine level was also reduced, mean dopamine and serotonin levels were significantly higher than in mice given MPTP alone. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine plasminogen Mus musculus
4 It is concluded that PLG could protect at least partially the neurotoxic effect of MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine plasminogen Mus musculus