Pub. Date : 2014 Jan 30
PMID : 24373833
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through sigma(1)-receptor in hypertrophic cardiomyocytes. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 2 | AIMS: We previously reported that fluvoxamine, a selective serotonin reuptake inhibitor with high affinity for the sigma1-receptor (sigma1R), ameliorates cardiac hypertrophy and dysfunction via sigma1R stimulation. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 3 | AIMS: We previously reported that fluvoxamine, a selective serotonin reuptake inhibitor with high affinity for the sigma1-receptor (sigma1R), ameliorates cardiac hypertrophy and dysfunction via sigma1R stimulation. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 4 | AIMS: We previously reported that fluvoxamine, a selective serotonin reuptake inhibitor with high affinity for the sigma1-receptor (sigma1R), ameliorates cardiac hypertrophy and dysfunction via sigma1R stimulation. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 5 | Interestingly, sigma1R stimulation with fluvoxamine rescued impaired mitochondrial Ca(2+) mobilization and ATP production, an effect abolished by treatment of cells with the sigma1R antagonist, NE-100. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 6 | Interestingly, sigma1R stimulation with fluvoxamine rescued impaired mitochondrial Ca(2+) mobilization and ATP production, an effect abolished by treatment of cells with the sigma1R antagonist, NE-100. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 7 | SIGNIFICANCE: These results suggest that sigma1R stimulation with fluvoxamine promotes SR-mitochondrial Ca(2+) transport and mitochondrial ATP production, whereas sigma1R stimulation suppresses intracellular Ca(2+) overload through IP3Rs and RyRs. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 8 | These mechanisms likely underlie in part the anti-hypertrophic and cardioprotective action of the sigma1R agonists including fluvoxamine. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |