Title : Depression-like effect of prenatal buprenorphine exposure in rats.

Pub. Date : 2013

PMID : 24367510






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1 Since BDNF/serotonin and CREB signaling could orchestrate a positive feedback loop, our findings suggest that the induction of oxidative stress, reduction of BDNF and serotonin expression, and attenuation of CREB signaling induced by prenatal exposure to supra-therapeutic dose of buprenorphine provide evidence of potential mechanism for the development of depression-like neurobehavior. Buprenorphine brain-derived neurotrophic factor Rattus norvegicus