Pub. Date : 2014 Jan
PMID : 24362935
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transcriptome sequencing revealed genetic lesions in alternative NF-kappaB pathway signaling components in ibrutinib-insensitive cell lines, and sequencing of 165 samples from patients with MCL identified recurrent mutations in TRAF2 or BIRC3 in 15% of these individuals. | ibrutinib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Although they are associated with insensitivity to ibrutinib, lesions in the alternative NF-kappaB pathway conferred dependence on the protein kinase NIK (also called mitogen-activated protein 3 kinase 14 or MAP3K14) both in vitro and in vivo. | ibrutinib | nuclear factor kappa B subunit 1 | Homo sapiens |