Title : Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor.

Pub. Date : 2014 Jan

PMID : 24361480






2 Functional Relationships(s)
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1 Here we describe a strategy to conveniently obtain metal-based PARP-1 inhibitors with enhanced biological activities by conjugating platinum moiety with an original inhibitor, e.g., benzonaphthyridone. Platinum poly(ADP-ribose) polymerase 1 Homo sapiens
2 Our study implies that the conjugation of platinum with PARP-1 inhibitors could be a valid strategy to obtain more potent anticancer agents with improved biological activities. Platinum poly(ADP-ribose) polymerase 1 Homo sapiens