Pub. Date : 2014 Mar
PMID : 24357089
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PG/PK study of indapamide demonstrated that the polymorphic SNPs CYP2C9 rs4918758 and CYP2C19 rs4244285 appeared to confer lowered enzyme activity, as indicated by increased C max (25% ~ 64%), increased area under the plasma level-time curves (30~76%), increased area under the time infinity (43% ~ 80%), and lower apparent clearance values than PK for wild-type indapamide. | Indapamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The PG/PK study of indapamide demonstrated that the polymorphic SNPs CYP2C9 rs4918758 and CYP2C19 rs4244285 appeared to confer lowered enzyme activity, as indicated by increased C max (25% ~ 64%), increased area under the plasma level-time curves (30~76%), increased area under the time infinity (43% ~ 80%), and lower apparent clearance values than PK for wild-type indapamide. | Indapamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Our results reinforce the biochemical support of CYP2C19 in indapamide metabolism and identify a possible new participating enzyme CYP2C9. | Indapamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |