Title : Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.

Pub. Date : 2014 Dec 1

PMID : 24346863






1 Functional Relationships(s)
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1 Additionally, the use of simvastatin plus classII histone deacetylase (HDAC) inhibitor (MC1568) induced further overexpression of p27(KIP1) by inhibiting HDAC5 induction originated from downregulated EZH2 in CRC cells and synergistically led to considerable antiproliferative effects. MC1568 histone deacetylase 5 Homo sapiens