Title : Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.

Pub. Date : 2014 Jun

PMID : 24339057






1 Functional Relationships(s)
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1 In contrast, mutant p62 expression in OCL precursors promotes receptor activator of NF-kappaB ligand (RANKL) hyperresponsivity and increased OCL production, but OCLs that form have normal morphology, are not hyperresponsive to 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3 ), nor produce elevated levels of IL-6. Calcitriol sequestosome 1 Mus musculus