Title : Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

Pub. Date : 1987 Feb 5

PMID : 2433285






3 Functional Relationships(s)
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1 First, EGF stimulated the breakdown of phosphatidylinositol 4,5-diphosphate to diacylglycerol and an inositol triphosphate. Inositol triphosphate epidermal growth factor Homo sapiens
2 The EGF-dependent increases in both inositol triphosphate production and phosphatidylinositol 4-monophosphate levels were inhibited by pretreatment of the cells with 12-O-tetradecanoylphorbol-13-acetate. Inositol triphosphate epidermal growth factor Homo sapiens
3 These data demonstrate that EGF stimulates the production of inositol triphosphate. Inositol triphosphate epidermal growth factor Homo sapiens